|
Anxiety Disorders
|
0.210 |
Biomarker
|
group |
BEFREE |
The hyperpolarization-activated cyclic nucleotide-gated channel 1(HCN1) could be inhibited by the ketamine, a drug to alleviate depression and anxiety, and regulated the BDNF expression, however, the effects of ketamine in alleviating PTSD symptoms by regulating the HCN1-related BDNF have been poorly perceived.
|
29596995 |
2018 |
|
Anxiety Disorders
|
0.210 |
Biomarker
|
group |
RGD |
Our results suggest that HCN1 protein could be a potential target for treatment of anxiety and depression disorders.
|
22884333 |
2012 |
|
Mood Disorders
|
0.200 |
Biomarker
|
group |
RGD |
Enhancement of dorsal hippocampal activity by knockdown of HCN1 channels leads to anxiolytic- and antidepressant-like behaviors.
|
22884333 |
2012 |
|
Child Development Disorders, Pervasive
|
0.100 |
GeneticVariation
|
group |
GWASCAT |
Meta-analysis of GWAS of over 16,000 individuals with autism spectrum disorder highlights a novel locus at 10q24.32 and a significant overlap with schizophrenia.
|
28540026 |
2017 |
|
Encephalopathies
|
0.100 |
Biomarker
|
group |
HPO |
|
|
|
|
Intellectual Disability
|
0.100 |
Biomarker
|
group |
HPO |
|
|
|
|
Neuropathy
|
0.020 |
Biomarker
|
group |
BEFREE |
Selective HCN1 block as a strategy to control oxaliplatin-induced neuropathy.
|
29339292 |
2018 |
|
Neuropathy
|
0.020 |
AlteredExpression
|
group |
BEFREE |
In the current study, we used a neuropathy rat model induced by chronic constriction injury (CCI) of sciatic nerve to evaluate the change of expression of HCN1/HCN2 mRNA in peripheral nerve and spinal cord.
|
27901476 |
2017 |
|
Secondary Neoplasm
|
0.010 |
Biomarker
|
group |
BEFREE |
In this study, we investigated whether single nucleotide polymorphisms (SNPs) identified by genome-wide association study (GWAS) (MAP3K1, FGFR2, TNRC9, HCN1, and 5p12), and SNPs involved in the metabolism of estrogen (CYP19, COMT, ESR1, and UGT1A1), tamoxifen (CYP2C9, CYP2C19, CYP3A5, and CYP2D6), and chemotherapeutic agents (ABCB1, ALDH3A1, and CYP2B6) are associated with the prognoses of 414 hormone receptor (HR)-positive early breast cancers with negative or 1 to 3 nodal metastases.
|
28178648 |
2017 |
|
Seizures
|
0.440 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Seizures
|
0.440 |
AlteredExpression
|
phenotype |
BEFREE |
Aberrant SUMOylation has been linked to neurological diseases that also display alterations in HCN1 and HCN2 channel expression, such as seizures and Parkinson's disease.
|
28127275 |
2016 |
|
Seizures
|
0.440 |
Biomarker
|
phenotype |
BEFREE |
The Hcn1-knockout rats were also more vulnerable to pentylenetetrazol-induced acute convulsions.
|
30408474 |
2019 |
|
Seizures
|
0.440 |
Biomarker
|
phenotype |
BEFREE |
Two experiments were performed: (1) cortical expression of ion channels Nav1.1, Nav1.6, and HCN1 (previously shown to be dysregulated in WAG/Rij) measured by immunocytochemistry in adult treated rats; and (2) electroencephalogram (EEG) recordings to measure seizure severity at serial time points after stopping the treatment.
|
18070091 |
2008 |
|
Seizures
|
0.440 |
GeneticVariation
|
phenotype |
BEFREE |
In contrast, no change in HCN1 transcript was noted at an age prior to seizure expression or in a SWD-free model in which the R43Q mutation has been crossed into a seizure-resistant genetic background.
|
24368169 |
2014 |
|
Seizures
|
0.440 |
Biomarker
|
phenotype |
CTD_human |
Therefore, down-regulation of HCN1 associated with human epilepsy and rodent models may be a contributing factor in seizure behavior.
|
20384728 |
2010 |
|
Ataxia
|
0.400 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Ataxia
|
0.400 |
Biomarker
|
phenotype |
CTD_human |
In this study we showed that the motor coordination impairment observed in HCN1-/- mice is paralleled by a decline of GABA content in the cerebellum.
|
19747469 |
2009 |
|
Abnormal coordination
|
0.400 |
Biomarker
|
phenotype |
CTD_human |
Gabapentin treatment improves motor coordination in a mice model of progressive ataxia.
|
19747469 |
2009 |
|
Abnormal coordination
|
0.400 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Absence Seizures
|
0.400 |
Biomarker
|
phenotype |
CTD_human |
Increased seizure severity and seizure-related death in mice lacking HCN1 channels.
|
20384728 |
2010 |
|
Absence Seizures
|
0.400 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Convulsions
|
0.310 |
Biomarker
|
phenotype |
CTD_human |
Increased seizure severity and seizure-related death in mice lacking HCN1 channels.
|
20384728 |
2010 |
|
Convulsions
|
0.310 |
Biomarker
|
phenotype |
BEFREE |
The Hcn1-knockout rats were also more vulnerable to pentylenetetrazol-induced acute convulsions.
|
30408474 |
2019 |
|
Epileptic Seizures
|
0.310 |
Biomarker
|
phenotype |
CTD_human |
Increased seizure severity and seizure-related death in mice lacking HCN1 channels.
|
20384728 |
2010 |
|
Epileptic Seizures
|
0.310 |
Biomarker
|
phenotype |
BEFREE |
Taken together, HCN1 is proposed to play an important role in the molecular linkage between epileptic seizures and Aβ generation, and in the aggravation of sporadic AD.
|
23034178 |
2012 |